The 91st China Pharmaceutical apis/Intermediates/Packaging/Equipment Trade Fair (API China) and the 29th China International Pharmaceutical (Industry) Exhibition and Technology Exchange Conference (CHINAPHARM) will be held at Xi 'an International Convention and Exhibition Center on October 16-18, 2024. The 91st API China & the 29th CHINA-PHARM, as the industry feast of CHINA's pharmaceutical industry in 2024, we will work together with pharmaceutical people, go all out, and will join hands with more than 1,200 pharmaceutical apis, intermediates, pharmaceutical excipients, pharmaceutical packaging, and pharmaceutical equipment enterprises. With more than 4,000 pharmaceutical manufacturing enterprises and nearly 30,000 pharmaceutical industry colleagues, innovative cooperation, looking for vitality. Promote industrial upgrading with innovation, shape the new advantages of the development of China's pharmaceutical industry, and work with colleagues in the pharmaceutical industry to create a strong toughness, high safety, and constantly changing the length and width of the industrial chain.
Colistin sulfate, also known as colistin sulfate, is a "polypeptide antibiotic" in antibiotics. It mainly acts on the bacterial cell membrane and causes its permeability to increase, resulting in the leakage of important life substances in the cell and the bactericidal effect. It is currently the most sensitive veterinary antibiotics, coupled with its unique antibacterial action mechanism does not conflict with other antimicrobials, so it is synergistic with other antibiotics/antimicrobials. 1. Pharmacological properties Colistin sulfate is white or slightly yellow powder, pure product is white or white powder, easily soluble in water. Odorless or almost odorless, bitter, hygroscopic. Easily dissolved in water, slightly soluble in ethanol, almost insoluble in acetone, chloroform or ether (Pharmacopoeia Commission of the People's Republic of China 2000), the aqueous solution is left-handed, and the pure powder performance is stable and can be stored at 100℃ for 9 days, and the activity remains unchanged at 40℃ for 60 days. Its pH value is 3-7.5 stable, easy to decompose in strong acidic and alkaline solutions, heat resistant, digestive tract is not easy to absorb, rapid excretion, little toxicity, no side effects, easy to dissolve in water, not easy to produce drug-resistant strains is one of the safest livestock and poultry growth promotion antibiotics. 2, pharmacodynamic function Colistin sulfate is an alkaline polypeptide antibiotic, a narrow spectrum fungicide. It is used to prevent and control the infection of sensitive bacteria and promote the growth of livestock and poultry. It has strong antibacterial action against gram-negative bacteria, especially Escherichia coli, Salmonella, Pasteurella, dysentery bacillus, Pseudomonas aeruginosa, Proteus and Haemophilus. Mainly through the damage of bacterial cell membrane, increase its permeability, so that amino acids, purines, pyrimidines in the bacterial body leakage, but also affect the function of nucleoplasm and ribosome, resulting in bacterial death.
According to the relevant provisions of the Food Safety Law of the People's Republic of China and its implementing regulations, as well as the Jining City Food Safety Supervision and Sampling Plan, in order to further ensure food safety, the Jining City Market Supervision Bureau conducted supervision and sampling of 446 batches of samples from 28 major categories of food, including processed grain products, seasonings, edible agricultural products, edible oils, fats and their products, dairy products, sugar, tea and related products, alcoholic beverages, frozen drinks, vegetable products, food additives, canned foods, fruit products, stir fried foods and nut products, starch and starch products, soy products, beverages, egg products, biscuits, pastries, potatoes and puffed foods, frozen foods, candy products, meat products, convenience foods, bee products, catering foods, and aquatic products. Food, edible agricultural products Sixteen batches of samples from three major categories of food, including stir fried foods and nut products, were found to be unqualified, with excessive residues of agricultural and veterinary drugs, substandard quality indicators, and other pollutants detected. The fresh eggs sold by the Yijie Comprehensive Business Department in Zoucheng City, which are claimed to be produced by the Yingjie Egg Chicken Farm in Qufu City, do not comply with the national food safety standards for metronidazole. The market supervision department in the jurisdiction where the production and operation operators are located has ordered the enterprise to investigate the product flow, recall and remove the unqualified products, control risks, and analyze the reasons for rectification for the unqualified products found in the above-mentioned sampling. The unqualified products involved have been inspected and disposed of as required. Metronidazole is a type of antibiotic, and the "List of Prohibited Veterinary Drugs and Other Compounds for Food Animals" clearly states that it is not allowed to be used for the purpose of anti stress, improving feed efficiency, and promoting animal growth in the process of food animal feeding, and cannot be detected in all animal foods. Eggs contain metronidazole, which is generally related to the medication used by farmers during the feeding process of laying hens. Consumers who consume eggs containing metronidazole for a long time without their knowledge will develop certain drug resistance in the human body, affecting their health.
