CAS： 59-05-2
MF： C20H22N8O5
Appearance： yellow crystalline powder
Quality products make an important contribution to long-term revenue and profitability.
Methotrexate is a medication that treats arthritis, psoriasis and other inflammatory conditions. It decreases inflammation in your body.
L-p-methylaminobenzoyl glutamate zinc salt
6-bromomethylpterin
![N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid](/upload/2024/9/35ed87d9-b422-4291-878e-58ed79709906.png)
N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
| Conditions | Yield |
|---|---|
|
With hydrogen bromide; In water; at 55 ℃; for 2.2h; Temperature; Reagent/catalyst;
|
56.2% |
L-glutamic acid
![4-{[N-[(2,4-diamino-6-pteridinyl)methyl]-N-methyl]amino}benzoyl azide](/upload/2024/9/77ebff0c-857c-4ab1-8acc-96b50cee439d.png)
4-{[N-[(2,4-diamino-6-pteridinyl)methyl]-N-methyl]amino}benzoyl azide
N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
| Conditions | Yield |
|---|---|
|
With 1,1,3,3-tetramethylguanidine; In dimethyl sulfoxide; at 25 ℃; for 1h;
|
100% |
The CAS number of Methotrexate is 59-05-2.
Synonyms for Methotrexate 59-05-2:Glutamicacid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, L-(+)-(8CI);(+)-Amethopterin;Amethopterin;Amethopterine;Antifolan;CL 14377;EMT 25299;Emtexate;Emthexate PF;L-Amethopterin;L-Methotrexate;Ledertrexate;Metatrexan;Mexate;N-[p-[[2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-(+)-glutamicacid;NSC 740;R 9985;Rheumatrex;Trexall;
The chemical formula of Methotrexate is C20H22N8O5 which containing 20 Carbon atoms,22 Hydrogen atoms,8 Nitrogen atoms and 5 Oxygen atoms,and the molecular weight of Methotrexate is 454.445.
Methotrexate is generally the first-line drug for the treatment of RA, psoriatic arthritis and other forms of inflammatory arthritis, and it enhances the effect of most biologic agents in RA. Methotrexate calms your immune system, to help stop it attacking your body's cells. This helps reduce the swelling (inflammation) that causes swollen and stiff joints in rheumatoid arthritis, thickened skin in psoriasis or damage to your bowel in Crohn's disease.
InChI:InChI=1/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m1/s1
Relevant articles related to Methotrexate:
|
Article |
Source |
| Methotrexate mechanism in treatment of rheumatoid arthritis |
Although there has been development of numerous new targeted therapies for rheumatoid arthritis (RA) in recent years, methotrexate has remained the “anchor drug” for most patients since the late 1980s [1]. However, despite its long-term and widespread use for RA, the precise mechanism of this drug remains elusive. , Benjamin Friedman , Bruce Cronstein , Joint Bone Spine Volume 86, Issue 3, May 2019, Pages 301-307 |
| Methotrexate and its mechanisms of action in inflammatory arthritis |
Although methotrexate is one of the first examples of intelligent drug design, multiple mechanisms potentially contribute to the anti-inflammatory actions of methotrexate, including the inhibition of purine and pyrimidine synthesis, transmethylation reactions, translocation of nuclear factor-κB (NF-κB) to the nucleus, signalling via the Janus kinase (JAK)–signal transducer and activator of transcription (STAT) pathway and nitric oxide production, as well as the promotion of adenosine release and expression of certain long non-coding RNAs. , Bruce N. Cronstein & Thomas M. Aune , Nature Reviews Rheumatology volume 16, pages145–154 (2020) |
Hebei KuiSheng Trading Co., LTD is a quality supplier of Methotrexate. Our main goal is customer satisfaction. Hebei KuiSheng Trading Co., LTD ，a company specializing in the production and supply of chemicals for various industries. we take pride in our ability to carefully formulate chemicals that meet the highest standards of quality, efficiency, and safety. Through advanced technology and strict quality control measures, we ensure that our products consistently deliver exceptional performance and reliability. Whether you are in need of chemicals for pharmaceutical, agricultural, or industrial applications, we offer a wide range of solutions to meet your specific requirements. We would greatly appreciate the opportunity to work with you and contribute to the success of your business. Should you require any further information or have specific inquiries, please do not hesitate to contact us. We look forward to heari.
