Ethylenebis(oxyethylenenitrilo)tetraacetic acid

Base Information

  • PRODUCT:Ethylenebis(oxyethylenenitrilo)tetraacetic acid
  • CAS.:67-42-5
  • MF:C14H24N2O10
  • Molecular Weight:380.352
  • Purity:99%

Product Details

CAS: 67-42-5

MF: C14H24N2O10

Appearance: white to slightly off-white powder

Ethylenebis(oxyethylenenitrilo)tetraacetic acid Good Supplier In Bulk Supply High Purity 67-42-5

  • Molecular Formula:C14H24N2O10
  • Molecular Weight:380.352
  • Appearance/Colour:white to slightly off-white powder 
  • Vapor Pressure:3.76E-20mmHg at 25°C 
  • Melting Point:241 °C (dec.)(lit.) 
  • Refractive Index:1.4590 (estimate) 
  • Boiling Point:678.016 °C at 760 mmHg 
  • PKA:1.47±0.10(Predicted) 
  • Flash Point:363.851 °C 
  • PSA:174.14000 
  • Density:1.433 g/cm3 
  • LogP:-2.03800 

Ethylenebis(oxyethylenenitrilo)tetraacetic acid(Cas 67-42-5) Usage

Description Ethylenebis(oxyethylenenitrilo)tetraacetic acid (EGTA) is a diether, with ethylene glycol's hydroxy groups replaced by 2-[bis(carboxymethyl)amino]ethyl groups.
Function Ethylenebis(oxyethylenenitrilo)tetraacetic acid (EGTA) acts as a calcium chelator, protecting against cell death caused by nitric oxide-induced calcium influx into nerve cells.
Comparison with EDTA Studies in rats showed that both EGTA and EDTA influence calcium and phosphorus excretion. Unlike EDTA, EGTA does not increase hydroxyproline excretion, suggesting a specific role in calcium chelation.
Metal Ion Interaction In studies with Euphorbia lathyris, EGTA enhanced biosynthesis of triterpenols and fatty acid esters when used as a metal ion chelator.

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of NOx. See also GLYCOL ETHERS.

Purification Methods

Dissolve EGTA in aqueous NaOH, precipitate it by adding aqueous HCl, wash it with water and dry at 100o in vacuo.[Beilstein 4 IV 217.]

Toxicity Poisonous when administered by intraperitoneal route; moderately toxic if ingested.

InChI:InChI=1/C14H24N2O10/c17-11(18)7-15(8-12(19)20)1-3-25-5-6-26-4-2-16(9-13(21)22)10-14(23)24/h1-10H2,(H,17,18)(H,19,20)(H,21,22)(H,23,24)/p-2

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67-42-5 Relevant articles

Effects of ethylenediaminetetraacetate (EDTA) on urinary excretion of hydroxyproline, calcium and phosphorus in the rat

D. N. Kalu, B. C. Miyasaki & G. V. Foster

, Calcified Tissue Research, Volume 16, pages 1–12, (1974)

To determine whether the changes induced by sodium EDTA are due to lowering of plasma calcium, rats were infused with 4.84 mM ethylenebis(oxyethylenenitrilo)tetraacetic acid (EGTA), a more specific calcium chelator. EGTA increased the urinary excretion of calcium and phosphorus (P<0.001) but not hydroxyproline in thyroparathyroidectomized rats.

Enhancement of Terpenoid Biosynthesis from Mevalonate in a Fraction of the Latex from Euphorbia lathyris

George J. Piazza, James A. Holzwarth

, Plant Physiology, Volume 89, Issue 2, February 1989, Pages 681–686

Conditions for improved incorporation were determined. CaCl2 or CaCl2 plus MnCl2 stimulated biosynthesis, and the metal ion chelator, ethylenebis(oxyethylenenitrilo)tetraacetic acid (EGTA) enhanced stimulation. Ethylenediaminetetraacetic acid was almost as effective as EGTA, but phthalic acid and citric acid were relatively poor stimulators.

67-42-5 Process route

3,6-dioxa-1,8-diaminooctane
929-59-9,892154-56-2

3,6-dioxa-1,8-diaminooctane

chloroacetic acid
79-11-8

chloroacetic acid

ethylene glycol-bis(2-aminoethyl)-N,N,N'N,'-tetraacetic acid
67-42-5

ethylene glycol-bis(2-aminoethyl)-N,N,N'N,'-tetraacetic acid

Conditions
Conditions Yield
With sodium hydroxide;
 
ethylene glycol-bis(2-aminoethyl)-N,N,N'N,'-tetraacetic acid
67-42-5

ethylene glycol-bis(2-aminoethyl)-N,N,N'N,'-tetraacetic acid

Conditions
Conditions Yield
 
 
 
 
 
 
 
 

67-42-5 Upstream products

  • 929-59-9
    929-59-9

    3,6-dioxa-1,8-diaminooctane

  • 79-11-8
    79-11-8

    chloroacetic acid

67-42-5 Downstream products

  • 50-00-0
    50-00-0

    formaldehyd

  • 124-38-9
    124-38-9

    carbon dioxide

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