CAS： 31282-04-9
MF： C20H37N3O13
Appearance： Amorphous solid or tan powder.
Hygromycin B is an aminoglycoside antibiotic produced by Streptomyces hygroscopicus that disrupts protein synthesis by interfering with the translocation of the 70S ribosome subunit and inducing mRNA misreading. It is widely used in livestock feed to control parasites and enhance growth in swine and poultry and plays a crucial role in laboratory research, particularly in cell culture and gene transfer experiments where it selects for hygromycin-resistant cells. In addition, it is used in yeast plate preparation and transformation studies. Beyond its traditional applications, hygromycin B has been explored for its ability to influence fungal secondary metabolite profiles, such as activating the production of the novel compound truncaaldehyde. Recent advancements in understanding its biosynthesis using CRISPR-Cas9 have identified key enzymes like HygJ, HygL, HygD, HygY, and HygM, which perform critical steps such as dehydrogenation, transamination, and methylation, unveiling a detailed biosynthetic pathway for this versatile antibiotic.
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