CAS： 96-50-4
MF： C3H4N2S
Appearance： Light brown crystals or brown granular solid.
| Chemical Class | Important scaffold widely found in natural and synthetic compounds. |
| Structure | 2-Aminothiazole contains a thiazole core (a five-membered heterocycle with sulfur and nitrogen at 1,3 positions) and an amino group at the 2-position. |
| Key Role | The amino group allows for linking to other active fragments, making 2-aminothiazole highly versatile in medicinal chemistry. |
| Structure-Activity Relationships (SAR) | The SAR studies help in rationally designing more effective anti-cancer agents containing the 2-aminothiazole core. |
|
Biochem/physiol Actions |
2-Aminothiazoles are potent cyclin-dependent kinase 5 inhibitors and are therapeutic agents for the treatment of Alzheimer′s disease and other neurodegenerative disorders. |
|
Safety Profile |
Poisonous if ingested or introduced intraperitoneally; can ignite spontaneously at 100°C. Explosive when mixed with nitric or nitric-sulfuric acids. |
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Purification Methods |
Crystallizes from petroleum ether (boiling point 100–120°C) or ethanol. |
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Definition |
ChEBI: A primary amino compound that is 1,3-thiazole substituted by an amino group at position 2. |
| Therapeutic Uses | Beyond anti-cancer, 2-aminothiazole derivatives have shown anti-microbial, anti-bacterial, and anti-fungal activities. |
InChI:InChI=1/C3H4N2S/c4-3-5-1-2-6-3/h1-2H,(H2,4,5)
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Literature survey documented that different 2-aminothiazole analogs exhibited their potent and selective nanomolar inhibitory activity against a wide range of human cancerous cell lines such as breast, leukemia, lung, colon, CNS, melanoma, ovarian, renal, and prostate. In this paper, we have reviewed the progresses and structural modification of 2-aminothiazole to pursuit potent anticancers and also highlighted in vitro activities and in silico studies. The information will useful for future innovation.
In recent years, many 2-aminothiazole derivatives with other bioactivities have been explored by many researchers. In this review, we aim to summarize the recent development of 2-aminothiazole as a privileged scaffold in anti-cancer agents discovery. In addition, the corresponding structure-activity relationships (SARs) of these anti-cancer agents are also probed to offer an insight to design more effective anti-cancer agents containing 2-aminothiazole core rationally.
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