CAS： 378-44-9
MF： C22H29FO5
Appearance： white to off-white solid
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Description |
Betamethasone is a steroid medication. |
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Acute toxicity |
Oral-mouse LD50:> 4500 mg/kg |
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Flammability and hazard characteristics |
Combustible;Its combustion produces toxic fumes of fluoride. |
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Storage Characteristics |
Ventilated, low-temperature ,dry storeroom. |
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Extinguishing agent |
Dry powder , foam, sand, carbon dioxide, water spray. |
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Manufacturing Process |
Betamethasone acetate is converted to betamethasone by means of hydrochloric acid in a methanol-chloroform-water mixture as described in US Patent 3,164,618. |
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Therapeutic Function |
Glucocorticoid |
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Flammability and Explosibility |
Nonflammable |
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Biochem/physiol Actions |
Betamethasone, an?isomer?of dexamethasone is also termed as 9α-fluoro-16β-methyl-11 β,17,21-trihydroxypregna-1,4-dien-3,20-dione or 9α-fluoro-16β-methylprednisolone (27.1.52). It can be used as an anti-itch agent and treating dermatitis?and?eczema. |
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Side effects |
Common Side Effects: Stinging, burning, itching, irritation, dryness, redness, stretch marks, skin thinning or discoloration, acne. Serious Side Effects: Skin infections, severe rash, dizziness, trouble breathing. |
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Safety Profile |
Low toxicity by ingestion. Anexperimental teratogen. Other experimental reproductiveeffects. When heated to decomposition it emits toxicfumes of F-. |
| Mechanism of Action | Reduces inflammation by inhibiting the release of chemicals that cause swelling, redness, and itching in response to irritation or allergic reactions. |
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Drug interactions |
Potentially hazardous interactions with other drugs Aldesleukin: avoid concomitant use. Antibacterials: metabolism accelerated by rifampicin; metabolism possibly inhibited by erythromycin; concentration of isoniazid possibly reduced. Anticoagulants: efficacy of coumarins and phenindione may be altered. Antiepileptics: metabolism accelerated by carbamazepine, fosphenytoin, phenobarbital, phenytoin and primidone. Antifungals: increased risk of hypokalaemia with amphotericin - avoid; metabolism possibly inhibited by itraconazole and ketoconazole. Antivirals: concentration possibly increased by ritonavir. Ciclosporin: rare reports of convulsions in patients on ciclosporin and high-dose corticosteroids. Cobicistat: concentration of betamethasone possibly increased. Diuretics: enhanced hypokalaemic effects of acetazolamide, loop diuretics and thiazide diuretics. Vaccines: high dose corticosteroids can impair immune response to vaccines; avoid with live vaccines. |
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Metabolism |
Corticosteroids are metabolised mainly in the liver but also in other tissues, and are excreted in the urine. The slower metabolism of the synthetic corticosteroids with their lower protein-binding affinity may account for their increased potency compared with the natural corticosteroids. |
| Onset of Action | For skin conditions: Improvement usually starts within a few days. For conditions like bursitis, arthritis, and foot issues: Symptom relief often occurs within 3-4 days. |
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Category |
Toxic substances |
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Brand name |
Celestone Syrup and Tablets (Schering). |
InChI:InChI=1/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
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Infants who are born at 34 to 36 weeks of gestation (late preterm) are at greater risk for adverse respiratory and other outcomes than those born at 37 weeks of gestation or later. It is not known whether betamethasone administered to women at risk for late preterm delivery decreases the risks of neonatal morbidities. Administration of betamethasone to women at risk for late preterm delivery significantly reduced the rate of neonatal respiratory complications.
The neonates receiving betamethasone suffered more from respiratory distress syndrome (49% versus 31%, p = 0.008, RR = 1.59 95% CI (1.12–2.27)) and requiring more respiratory support (71% versus 50%, p = 0.002, RR = 1.43 95% CI (1.13–1.80)) as compared to the control group. There was no difference between the two groups in other neonatal adverse events or death.
A novel and efficient synthesis of betam...
betamethasone dipropionate
betamethasone
Betamethasone propionate
betamethasone 21-monopropionate
| Conditions | Yield |
|---|---|
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With sulfuric acid; In acetonitrile; at 20 ℃; for 20h; Further Variations:; Temperatures; Product distribution;
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betamethasone dipropionate
betamethasone
Betamethasone propionate
6β-hydroxybetamethasone
6β-hydroxybetamethasone 17-propionate
| Conditions | Yield |
|---|---|
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With phosphate buffer; air; plasma of 20 d pregnant Sprague-Dawley rat; at 37 ℃; for 1h; Product distribution; metabolism with tissues (plasma, liver, brain, placenta) from mothers and fetuses of Sprague-Dawley rats sacrificed on day 20 of pregnancy and mice on day 17 of pregnancy, further in vivo;
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67.8 % Chromat. 2.3 % Chromat. 14.8 % Chromat. 1.4 % Chromat. |
betamethasone dipropionate
betamethasone 21-acetate
16α,17α-epoxy-3β-hydroxy-5α-pregn-9(11)-en-20-one
16β-methyl-9β,11β-epoxy-17α-hydroxy-1,4-pregnadiene-3,20-dione
9α-fluoro-11β,17α-dihydroxy-16β-methyl-3-oxo-androsta-1,4-diene-17β-carboxylic acid
Betamethasone propionate
9α-fluoro-11β,17α,21-trihydroxy-16β-methyl-1,4-pregnadiene-3,20-dione 17-butyrate
betamethasone-valerate
