CAS： 13154-24-0
MF： C9H21ClSi
Appearance： Clear colorless liquid
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Preparation |
Method 1: Triisopropyl silane reacts with hydrochloric acid to chlorinate the hydrogen on silicon. Method 2: Silicon tetrachloride reacts with isopropyl lithium to form triisopropylchlorosilane. |
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Physical properties |
bp 198 °C/739 mmHg; d 0.901 g cm?3. |
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Application |
Triisopropylsilyl chloride is used as a basic intermediate in the synthesis of organosilicon materials. Functions as a blocking agent for silicone oils or silicone rubbers. |
| Hazards | Triisopropylsilyl chloride is corrosive, causing severe skin burns and eye damage, and reacts with water to produce toxic hydrogen chloride gas. |
| Supplier | Hebei KuiSheng Trading Co., LTD ，a company specializing in the production and supply of chemicals for various industries. we take pride in our ability to carefully formulate chemicals that meet the highest standards of quality, efficiency, and safety. Through advanced technology and strict quality control measures, we ensure that our products consistently deliver exceptional performance and reliability. Whether you are in need of chemicals for pharmaceutical, agricultural, or industrial applications, we offer a wide range of solutions to meet your specific requirements. Our team is dedicated to providing excellent customer service and we strongly believe in establishing long-lasting business relationships built on trust and mutual success. |
InChI:InChI=1/C9H21ClSi/c1-7(2)11(10,8(3)4)9(5)6/h7-9H,1-6H3
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An efficient and practical procedure for the free α-carboxylic acid esterification of amino acid residues with β-(trimethylsilyl)ethoxymethyl chloride and triisopropylsilyl chloride is described. The reaction takes place under mild conditions and the expected protected amino acids are obtained in good to excellent yields. Our method provides a useful alternative for the C-terminal carboxylic acid protection of amino acids and peptides. Moreover, the removal of such protection was also achieved under mild conditions, without affecting either the other protecting groups at the α-amino moiety and side chains or the optical integrity at the α-position of the amino acid residues.
A new and efficient chlorination protoco...
Various types of carboxylic acids can be converted effectively to their corresponding TBDMS and TIPS esters using TBDMSCI and TIPSCI in the presence of imidazole under solvent-free conditions. The advantage of this modified method in comparison with that reported by Corey is the elimination of DMF, which eliminates aqueous work-up.
tri(iso-propyl)methoxysilane
triisopropylsilyl chloride
| Conditions | Yield |
|---|---|
|
With iron(III) chloride; acetyl chloride; In 1,2-dichloro-ethane; for 24h;
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88% |
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With hydrogenchloride; In water; at 20 ℃; for 10h;
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60% |
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With hydrogenchloride; at 24 ℃; for 2h;
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98 % Chromat. |
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Multi-step reaction with 2 steps
1: 100 percent / aq. HCl / tetrahydrofuran / 65 °C
2: 95 percent / aq. HCl / 2 h / 24 °C
With hydrogenchloride; In tetrahydrofuran;
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1-(triisopropylsilyl)oxybutane
triisopropylsilyl chloride
| Conditions | Yield |
|---|---|
|
With hydrogenchloride; In water; at 20 ℃; for 10h;
|
89% |
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With hydrogenchloride; In tetrahydrofuran; at 24 ℃; for 4h;
|
95 % Chromat. |
isopropyllithium
isopropyl chloride
chlorotriisopropylsilane
aluminium trichloride
triisopropyl(phenyl)silane
N-Triisopropylsilyl-benzophenonimin
1-(triisopropylsilyl)-1H-indole
4-methoxy-3-(trisopropylsilyl)pyridine
