CAS： 15180-02-6
MF： C18H16N2O3
Appearance： yellow powder
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AMFONELIC ACID is yellow powder, while it's Molecular Formula is C18H16N2O3. Amfonelic acid (AFA) is a non-amphetamine stimulant that affects dopamine metabolism in the brain. Our team is dedicated to providing excellent customer service and we strongly believe in establishing long-lasting business relationships built on trust and mutual success.
The CAS number of AMFONELIC ACID is 15180-02-6.
More information of AMFONELIC ACID 15180-02-6 are:
|
Synonyms |
1,8-Naphthyridine-3-carboxylicacid, 7-benzyl-1-ethyl-1,4-dihydro-4-oxo- (8CI);7-Benzyl-1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid;NSC 100638;Win 25978; |
|
CAS Number |
15180-02-6 |
|
Molecular Formula |
C18H16N2O3 |
|
Molecular Weight |
308.33 |
|
Density |
1.298 g/cm3 |
|
Melting Point |
>1000 °C |
|
Boiling Point |
499.308 °C at 760 mmHg |
|
Flash Point |
255.772 °C |
|
HS CODE |
2933990090 |
Amfonelic acid (AFA) has been shown to protect dopamine neurons from damage caused by methamphetamine. AFA increases the effects of the antipsychotic drugs haloperidol, trifluoperazine, and spiperone.
InChI:InChI=1/C18H16N2O3/c1-2-20-11-15(18(22)23)16(21)14-9-8-13(19-17(14)20)10-12-6-4-3-5-7-12/h3-9,11H,2,10H2,1H3,(H,22,23)
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| Pharmacologic properties and mechanism of action of amfonelic acid |
The pharmacologic properties and mechanism of action of amfonelic acid, a potent locomotor stimulant were investigated. Studies in reserpinized and α-methyl tyrosinized mice suggest that the locomotor effects of amfonelic acid are dependent on the presence of stored and/or functional norepinephrine and/or dopamine. Compared to (+)-amphetamine amfonelic acid shows weak isolated or aggregate group toxicity in mice. , European Journal of Pharmacology Volume 10, Issue 3, June 1970, Pages 344-354 |
| Different effects of amphetamine and amfonelic acid on peripheral and central catecholamine metabolism |
The effects of amphetamine (AMPH) and a non-amphetamine stimulant, amfonelic acid (AFA), on catecholamine metabolism in peripheral sympathetic ganglia (superior cervical and celiac) and several brain regions (hypothalamus, caudate, olfactory tubercle and nucleus accumbens) were examined. , European Journal of Pharmacology Volume 62, Issue 4, 4 April 1980, Pages 297-307 |
| Amfonelic acid, a non-amphetamine stimulant, has marked effects on brain dopamine metabolism but not noradrenaline metabolism: association with differences in neuronal storage systems | Journal of Pharmacy and Pharmacology, Volume 30, Issue 1, September 1978, Pages 464–466 |
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