CAS： 55-48-1
MF： 2(C17H23NO3).H2SO4
Appearance： White crystalline powder
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General Description |
Atropine sulfate is a drug that blocks nerve stimulation of muscles and glands, and relaxes smooth muscles. Atropine sulfate is a type of antimuscarinic agent and tropane alkaloid. It's derived from the naturally-occurring alkaloid atropine, which comes from the Atropa belladonna plant. |
| Uses | Atropine sulfate is one of the major lifesaving antidotes given for OP poisoning and acts by neutralizing the acetylcholine-like action of these chemical agents as a physiologic antagonist . It is generally given for SLUDGE (salivation, lacrimation, urination, diaphoresis, gastrointestinal motility, emesis) symptoms caused by organophosphate poisoning. |
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Safety Profile |
Poison by subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. Human (child) pulmonary system effects by ingestion. Human systemic effects: decreased body temperature, cardiac arrhythmias. An experimental teratogen. Other experimental reproductive effects. See also ATROPINE. When heated to decomposition it emits very toxic fumes of NO,xand SOx. |
| Handling | Avoid inhaling vapors or mists, swallowing, and prolonged or repeated skin contact. Wear safety glasses with side shields or goggles. |
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Veterinary Drugs and Treatments |
The principal veterinary indications for systemic atropine include: !!Preanesthetic to prevent or reduce secretions of the respiratory tract !!Treat sinus bradycardia, sinoatrial arrest, and incomplete AV block !!Differentiate vagally-mediated bradycardia for other causes !!As an antidote for overdoses of cholinergic agents (e.g., physostigmine, etc.) !!As an antidote for organophosphate, carbamate, muscarinic mushroom, blue-green algae intoxication !!Hypersialism !!Treatment of bronchoconstrictive disease |
| Exporter | Hebei KuiSheng Trading Co., LTD ，a company specializing in the production and supply of chemicals for various industries. we take pride in our ability to carefully formulate chemicals that meet the highest standards of quality, efficiency, and safety. Through advanced technology and strict quality control measures, we ensure that our products consistently deliver exceptional performance and reliability. Whether you are in need of chemicals for pharmaceutical, agricultural, or industrial applications, we offer a wide range of solutions to meet your specific requirements. Our team is dedicated to providing excellent customer service and we strongly believe in establishing long-lasting business relationships built on trust and mutual success. |
InChI:InChI=1/2C17H23NO3.H2O4S/c2*1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12;1-5(2,3)4/h2*2-6,13-16,19H,7-11H2,1H3;(H2,1,2,3,4)/t2*13-,14+,15+,16?;
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his was an in-vitro study using gas chromatography and mass spectrometry (GC/MS). Four atropine solutions (labeled concentration of 400 μg/mL) ranging from in date to 12 years beyond expiration (exp) and an additional sample of atropine sulfate (labeled concentration of 2,000 μg/mL) obtained from a World War II era autoinjector were assayed for atropine stability. Standards of atropine sulfate and tropine were prepared and quantified by GC/MS.
The objectives of the present study were to develop a novel atropine sulfate (AS) sublingual injection formulation, to create its bioavailability data in humans and to evaluate its suitability for field use with a view to obtain early therapeutic drug concentration in comparison to the conventional intramuscular route that provides a therapeutic peak of 6 to 8 ng/mL in blood at 30 minutes.
Atropine
atropine sulfate
| Conditions | Yield |
|---|---|
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With sulfuric acid; In dichloromethane; water; acetone; at 29 - 42 ℃; for 3.5h;
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85 g |
α-formyl phenyl acetic acid
atropine sulfate
| Conditions | Yield |
|---|---|
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Multi-step reaction with 3 steps
1: sodium methylate / toluene / 5 h / 109 - 115 °C
2: sodium tetrahydroborate; methanol / dichloromethane / 4 h / 0 - 20 °C
3: sulfuric acid / water; dichloromethane; acetone / 3.5 h / 29 - 42 °C
With methanol; sodium tetrahydroborate; sulfuric acid; sodium methylate; In dichloromethane; water; acetone; toluene;
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α-formyl phenyl acetic acid
Atropine
acetonedicarboxylic acid
tropinone
Noratropine
benzaldehyde
3-tropanol
(+)-Atropine
