CAS： 7585-39-9
MF： C42H70O35
Appearance： white powder
Hebei KuiSheng Trading Co., LTD ，a company specializing in the production and supply of chemicals for various industries. we take pride in our ability to carefully formulate chemicals that meet the highest standards of quality, efficiency, and safety. Through advanced technology and strict quality control measures, we ensure that our products consistently deliver exceptional performance and reliability. Whether you are in need of chemicals for pharmaceutical, agricultural, or industrial applications, we offer a wide range of solutions to meet your specific requirements. Our team is dedicated to providing excellent customer service and we strongly believe in establishing long-lasting business relationships built on trust and mutual success.
| Structure: | Cyclic oligosaccharide composed of seven glucose units linked by α-(1,4) glycosidic bonds. Cone-shaped with a hydrophobic inner cavity and a hydrophilic exterior. |
| Source: | Beta-cyclodextrin is derived from the breakdown of natural polymers, typically cellulose or starch. Commercially produced through Bacillus macerans or B. circulans fermentation of starch. |
| Safety: | Generally safe for oral use but nephrotoxic when administered parenterally (due to accumulation in kidneys). Not metabolized parenterally but broken down by colon microflora when ingested. Approved for use in food and pharmaceuticals in many countries. |
| Uses |
Beta-Cyclodextrin enhances solubility, stability, and bioavailability of drugs by forming inclusion complexes. Commonly used in tablet and capsule formulations, especially for direct compression (requires lubricant). |
|
Flammability and Explosibility |
Nonflammable |
| Acute Toxicity (LD50): | Mouse (IP): 0.33 g/kg; Rat (IP): 0.36 g/kg; Rat (IV): 1.0 g/kg; Rat (oral): 18.8 g/kg |
InChI:InChI=1/C42H70O35.H2O/c43-1-8-29-15(50)22(57)36(64-8)72-30-9(2-44)66-38(24(59)17(30)52)74-32-11(4-46)68-40(26(61)19(32)54)76-34-13(6-48)70-42(28(63)21(34)56)77-35-14(7-49)69-41(27(62)20(35)55)75-33-12(5-47)67-39(25(60)18(33)53)73-31-10(3-45)65-37(71-29)23(58)16(31)51;/h8-63H,1-7H2;1H2
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A higher EE was obtained (34.8%) for the inclusion complex 1:0.5 than for other molar rates. Both DSC and TGA of the inclusion complexes showed the presence of endothermic peaks between 80 °C and 150 °C, attributed to a complexation phenomenon. Antimicrobial tests for mycelial growth reduction under atmospheric conditions proved the fungistatic behaviour of the inclusion complexes against Botrytis cinerea.
As characterized by FTIR, mass spectrometry, elemental analysis, and NMR, mono-Ts-βCD was obtained with a molar purity of >98 mol %. From mono-Ts-βCD, β-cyclodextrin dimers linked by ethylenediamine (bis-Et-βCD) were successfully prepared (yield 93%, purity 96 mol %) in a one-step approach using an anion exchange resin to trap leaving groups that typically interfere in the reaction. This synthesis procedure with a direct collection of side-products may be a general strategy applicable for nucleophilic substitution of tosylated cyclodextrins.
